Intravenous (IV) infusion therapy is a treatment option for people who have been diagnosed with treatment-resistant mood disorders and chronic pain. The treatment is administered via a small IV catheter, in low doses, and in a comfortable, safe outpatient setting. Currently, there is an overwhelming amount of emerging evidence-based clinical data and research that has revealed results that are so dramatic in relation to the treatment of chronic pain and MDD that physicians and advanced practice nurses are bypassing usual protocols and medication that have proven to be inadequate time and time again. It is a new option to explore and it is making a lasting impression on patients and practitioners who have embraced it. It is providing an attainable goal, which is remission from these chronic afflictions, to those that have been left resigned from life.